Molecular diagnostic techniques spearhead the development of clinical laboratory diagnosis / 中华检验医学杂志

ABSTRACT

As a result of the molecular diagnosis blossoming , the time of clinical laboratory can be chronologically divided into two periods , the “pre-molecular diagnosis days” and the “post-molecular diagnosis days”.Functional genomics researches in the post-genome era reveal that gene encoding the drug metabolic enzyme influences on drug response.Based on studies of cell signaling pathways in targeted cancer therapy, curative effect is related to the mutations of corresponding target gene involved.Detection of the genotype and the specific mutation encouraged the era of specific diseases care into the era of individualized care, which allows the clinical laboratories working behind-the-scenes come to the fore in disease treatment.Gene amplification technology has been one of backbone technology used in molecular diagnosis.The key of whether the results of molecular diagnosis can be used in the diagnosis and treatment includes the standard laboratory partitions and the strict quality assurance measures during the pre -, during and post-analysis periods.The personnel team in future molecular diagnostic laboratory will consist of clinical laboratory physicians , pathologists , pharmacists and bioinformatics experts , genetic counselors and clinical experts, and so on.