Effects of hirudo capsules on platelet activation and blood rheology in patients with cerebral arteriosclerosis / 中国中西医结合急救杂志

ABSTRACT

Objective To observe the effects of hirudo capsules on degree of platelet activation and blood rheology in patients with cerebral arteriosclerosis. Methods 122 patients with cerebral arteriosclerosis were randomly divided into two groups by the random number tableobservation group(61 cases)and control group (61 cases). The two groups received conventional treatment such as antihypertensive and hypoglycemic drugs,and 100 mg of aspirin once a day. In the observation group,additionally hirudo capsules 0.75 g,3 times a day were given. The therapeutic course in both groups was 2 months. Prior to the start of treatment and on the next day after the end of treatment,traditional Chinese medicine(TCM)clinical syndrome integral,platelet membrane glycoproteins caspase 1 (PAC-1),platelet adhesion molecule P selection(CD62P)positive rate,and blood rheology indexes were detected,in addition to the adverse reactions . Results Before treatment,there were no statistical significant differences between the two groups in terms of TCM clinical syndrome integral such as headache,dizziness,head fullness,multiple somnolence amnesia,lip dark purple,sublingual veins purple in color,PAC-1,CD62P positive rate,hemorheology indexes(all P>0.05). After treatment,TCM clinical syndrome integral PAC-1,CD62P,low shear viscosity,high shear viscosity,plasma viscosity and the hematocrit of two groups were significantly lower than those before treatment, the improvement in observation group being more remarkable〔headache0.75±0.69 vs. 1.23±0.92,dizziness0.96±0.78 vs. 1.54±1.24,head fullness0.65±0.59 vs. 1.48±1.17,multiple somnolence amnesia0.77±0.72 vs. 1.69±1.14,lip dark purple0.83±0.81 vs. 1.32±0.79,sublingual veins purple0.84±0.67 vs. 1.20±0.74, PAC-1(10.31±4.57)%vs.(15.13±6.27)%,CD62P(11.39±5.24)%vs.(16.40±7.91)%,low shear viscosity (mPa?s)7.52±3.37 vs. 8.97±3.50,high shear viscosity(mPa?s)4.35±1.12 vs. 5.58±1.19,plasma viscosity (mPa?s)1.54±0.35 vs. 1.88±0.42,hematocrit(HCT)0.43±0.09 vs. 0.49±0.10〕. In the patients' follow-up, there were no obvious side effects of hirudo capsules. Conclusion Hirudo capsule is a safe and effective drug for treatment of patients with cerebral arteriosclerosis as it is helpful in reducing platelet activation degree and improving the blood rheology indexes.