Hyperventilation delays clinical induction of desflurane
Anesthesia and Pain Medicine
;
: 216-221, 2010.
Article
in Korean
| WPRIM
| ID: wpr-44612
ABSTRACT
BACKGROUND:
Ventilation is a major determinant of the alveolar concentration of inhaled anesthetics. Hyperventilation accelerates the equilibration of anesthetic in the lungs, but decelerates it in the brain. We evaluated this phenomenon for desflurane.METHODS:
Twenty healthy subjects were enrolled after IRB approval. End-tidal concentrations of desflurane (P.DESF) were recorded during 10 minutes of mask induction with 8% desflurane. P.DESF was modeled with time and end-tidal concentrations of CO2 (P.ETCO2) using a two-exponential pharmacokinetic equation. Bispectral index (BIS) values were also measured to find out the component reflecting the cerebral concentration of desflurane.RESULTS:
During induction, the rise of P.DESF could be separated into two components early and late rises. Individual BIS values showed a higher correlation with the late component of P.DESF (P = 0.000). P.ETCO2 had two different effects on the rise of P.DESF.CONCLUSIONS:
Hyperventilation hastened the early rise and delayed the late rise of P.DESF (P = 0.00, P = 0.00). Hyperventilation should be avoided to obtain rapid anesthesia induction with desflurane.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ventilation
/
Brain
/
Nonlinear Dynamics
/
Ethics Committees, Research
/
Hyperventilation
/
Isoflurane
/
Anesthesia
/
Anesthesia, Inhalation
/
Anesthetics
/
Lung
Language:
Korean
Journal:
Anesthesia and Pain Medicine
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS