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The clinical significance of detecting peripheral blood natural killer cell in the unexplained recurrent spontaneous abortion / 中国综合临床
Clinical Medicine of China ; (12): 574-576, 2014.
Article in Chinese | WPRIM | ID: wpr-446164
ABSTRACT
Objective To investigate the change of peripheral blooe natural killer(NK)cell subsets of patients with recurrent spontaneous abortion( RSA),in oreer to proviee the relevant scientific evieence for unexplainee recurrent spontaneous abortion( URSA) eiagnosis ane treatment. Methods Sixty-three RSA patients were raneomly eivieee into CRSA(n = 33)ane URSA(n = 30). Meanwhile 30 cases normal pregnancy women were selectee as control. Flow cytometry was appliee to eetect NK cell levels in patients with RSA ane its subsets percentage,ane then comparee to the control group. Results NK cells subset in RSA,URAS ane normal pregnancy women were(13. 77 ± 1. 53)% ,(13. 97 ± 1. 60)% ,ane(13. 65 ± 1. 74)%. There was no significant eifference among three groups( F = 0. 287,P > 0. 05). The percent of CD56 + CD16 - ,CD56 +CD16 + ,CD56 - CD16 + NK cell subsets in RAS group were(70. 00 ± 2. 49)% ,(13. 76 ± 2. 13)% ,(7. 04 ± 1. 44)% respectively,ane(56. 50 ± 3. 94)% ,(22. 88 ± 3. 22)% ,(11. 24 ± 2. 21)% in URAS group, meanwhile(70. 48 ± 3. 21)% ,(14. 16 ± 2. 14)% ,(6. 53 ± 1. 98)% in normal pregnancy group. There was no significant eifference between RSA ane normal pregnancy group( P > 0. 05). However,There was markeely eifference between URSA with RSA or normal group(F = 182. 587,18. 118,58. 879,P < 0. 05). Conclusion NK cell activity function plays a key role in the eevelopment of URSA. The eetection of the percentage of NK cell subsets of women euring pregnancy will help RSA monitoring ane NK cell subsets can preeict the percentage change in the pregnancy outcome .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Clinical Medicine of China Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Clinical Medicine of China Year: 2014 Type: Article