Analyse curative effect and immune indices of tripterygium glycosides on aged glomerulonephritis rats / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 627-629, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-446185
ABSTRACT
Objective:
To analyse the curative effect and immune indices of tripterygium glycosides on glomerulonephritis rats .Methods:
Aged Wistar rats were randomly divided into 3 groups , Group Aglomerulonephritis model rats received tripterygium glyco-sides treatment;Group Bhealthy Wistar rats received no treatment; Group C glomerulonephritis model rats received no treatment .Results:
12 weeks after experiment , Group A and Group C had higher levels of 24-hour urine protein than Group B and these of pre-experiment(P<0.05).Group A had a lower level of 24-hour urine protein than Group C(P<0.05).Group A and Group C had high-er levels of TG, TC than Group B, with lower levels of ALB than Group B (P<0.05).Group A had lower levels of TG, TC than Group C, but a higher level of ALB than Group C (P<0.05).Group A had a higher rate of 0-1 grades in pathology grade than group C(χ2 =6.667,P=0.010).Group C had higher levels of TNF-αand IL-6 than Group B and Group A (P<0.05).Conclusion:
Tripterygium glycosides can reduce the urine protein excretion of rats that with mesangial proliferative glomerulonephritis , rectify dyslip-idosis, raise plasma-albumin, decrease the protein expression of TNF-αand IL-6 in glomerulus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2014
Type:
Article
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