Detecting Thermal Stability of Cefmenoxime Hydrochloride in Infusion Solutions by Classical Isothermal Kinetic Method and Multivariate Linear Model / 医药导报
Herald of Medicine
;
(12): 668-671, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-446210
ABSTRACT
Objective To investigate thermal degradation kinetic characteristics of Cefmenoxime Hydrochloride in infusion solutions, and predict its thermal stability. Methods The HPLC was applied to determine the contents of Cefmenoxime Hydrochloride. Classical isothermal kinetic method and multivariate linear model were used to predict the expiration date of the injection. Results It was found that the thermal degradation kinetics of Cefmenoxime Hydrochloride in two infusion solutions corresponded with the first-order kinetics. The expiration dates of Cefmenoxime Hydrochloride in 0. 9%sodium chloride injection calculated by two different methods were 2. 20 days and 1. 52 days,and in 5% glucose injection were 2. 09 days and 1. 53 days,respectively. Conclusion The thermal stability of Cefmenoxime Hydrochloride in infusion solutions is poor and its expiration dates are the same calculated by two different methods.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Herald of Medicine
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS