The effects analysis of sodium aescinate adjuvant treating tibial plateau fracture / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical effects of sodium aescinate adjuvant in treatment with tibial plateau fracture. Method According to the principle of random draw, 160 cases of tibial plateau fractures patients were divided into observation group and control group, each had 80 cases. All cases were given the improved bilateral plate internal ifxation with conventional interventions, besides, the observation group were added intravenous infusion of sodium aescinate after surgery. Results The differences of operative time, blood loss and clinical fracture healing time between two groups were not signiifcant. After intervention, the overall incidence of complications with arthritis, deep vein thrombosis, joint stiffness and joint instability in observation group were signiifcantly lower than that in control group, but the value of joint activity with the HSS values were signiifcantly higher(P<0.05). The plasma TNF-αlevels between two groups before the intervention was not signiifcant, and the values were signiifcantly decreased after the intervention (P<0.05), and had signiifcant differences between the two groups (P<0.05). Conclusion Sodium aescinate has good effect on prognosis in treatment with tibial plateau fractures, the mechanism may be related to reducing the level of plasma TNF-α.