The correlation between mucosal healing and prognosis of ulcerative colitis / 中华消化内镜杂志
Chinese Journal of Digestive Endoscopy
;
(12): 80-83, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-447139
ABSTRACT
Objective To investigate the correlation between mucosal healing after treatment and prognosis of ulcerative colitis (UC).Methods UC patients who were remitted after treatment (n =82) were divided into MH group(ADA1,0-1 ; Geboes,0-1) and non-MH group (BDAI,0-1 ; Geboes,2-5) according to the assessment and were followed up for 2 years.The baseline characteristics,histological parameters,serologic indices (albumin,ESR,CRP,ANCA,IL-1 β,IL-6 and IL-15) at 0,12,24 months or recurrence and hospitalization,colon surgery,colon cancer were recorded.The correlation between mucosal healing and prognosis were assessed.Results There were no significant differences between group A and B in recurrence rate and recurrence time(P > 0.05).The multivariate Cox regression analysis showed that gender (female),past recurrence,pANCA and basal plasmacytosis were independent risk factors for recurrence of UC (P < 0.05).The rehospitalization rate [27.5% (group A) VS 44.1% (group B) ; P =0.018 ; OR=2.24,95%CI (1.11-3.98)] and colectomy rate [0% (group A) VS 17.6% (group B); P=0.035; OR =5.43,95% CI (2.14-7.64)] between groups have significant differences,however,rates of cancer [0% (group A) VS 2.7% (group B) ; P=0.643; OR =3.43,95%CI (0.14-7.64)] were not significantly different.Conclusion Mucosal healing after treatment is associated with UC prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Digestive Endoscopy
Year:
2014
Type:
Article
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