Effect of Cabergoline Treatment on Cushing's Disease Caused by Pituitary Macroadenoma after Incomplete Transsphenoidal Surgery
Soonchunhyang Medical Science
;
: 227-231, 2015.
Article
in Korean
| WPRIM
| ID: wpr-44725
ABSTRACT
The present case involves a 56-year-old woman with Cushing's disease due to pituitary macroadenoma. The patient had suffered from central obesity, general weakness for 1 year. Her serum cortisol levels were elevated throughout the observation period and the dexamethasone test failed to suppress the cortisol secretion. Plasma adrenocorticotropic hormone (ACTH) levels were significantly elevated (386 pg/mL). Sellar magnetic resonance imaging revealed a 3.1-cm pituitary tumor occupying the sellar region with extension to parasellar area. The pituitary mass was removed by transsphenoidal surgery incompletely and was pathologically identified as compatible to ACTH-producing pituitary adenoma by immunohistochemistry. Thereafter, cabergoline (1 mg/wk) was administered for the remnant adenoma, which gradually reduced ACTH levels in 7 days before starting radiation therapy. This case demonstrates the efficacy of cabergoline to treat Cushing's disease caused by pituitary macroadenoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
Plasma
/
Dexamethasone
/
Hydrocortisone
/
Immunohistochemistry
/
Magnetic Resonance Imaging
/
Adenoma
/
Adrenocorticotropic Hormone
/
Cushing Syndrome
/
ACTH-Secreting Pituitary Adenoma
Limits:
Female
/
Humans
Language:
Korean
Journal:
Soonchunhyang Medical Science
Year:
2015
Type:
Article
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