Determination of Residual Organic Solvents in Paclitaxel by Capillary GC / 中国药师
China Pharmacist
;
(12): 588-589, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-447310
ABSTRACT
Objective:
To establish a capillary GC method for the determination of residual organic solvents in paclitaxel. Meth-odsThe standard solution and test solution was respectively injected into an HP-INNOWAX sillica capillary column by headspace in-jection. The chromatograms were recorded with an FID. The injection port and detector temperature was 250℃ and 300℃, respective-ly, the initial column temperature was kept at 35℃ for 5 min, and then was risen to 260℃ at the rate of 25℃/min.Results:
The four residual organic solvents could be separated completely. The resolution and sensitivity were acceptable.Conclusion:
The method is proved to be simple, rapid, sensitive and reliable, and can be used in the determination of residual organic solvents in paclitaxel.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS