Clinical study on evaluation of severity of sepsis shock patients with myocardium injury / 中国医师进修杂志

ABSTRACT

Objective To explore the value of cardiac troponin Ⅰ (cTnI),brain natriuretic peptide (BNP),blood lactate and acute physiology and chronic health evaluation (APACHE) Ⅱ score which used to evaluate the severity of sepsis shock patients with myocardium injury.Methods Data of 61 patients with sepsis shock were collected,and cTnI,BNP,blood lactate were monitored and APACHE Ⅱ score were scored at admission,6,24 h after treatment.All of these indicators were compared between death group and survival group.Results In 61 patients,35 cases of them were lived (survival group),26 cases of them were died (death group).The cTnI,BNP,blood lactate and APACHE Ⅱ score at admission in death group was significantly higher than that in survival group (P＜ 0.05).In death group all of these indicators there was no significantly difference between admission and 6 h after treatment (P ＞0.05);24 h after treatment was significantly higher than that 6 h after treatment (P ＜ 0.05).In survival group 6,24 h after treatment was significantly lower than that at admission,24 h after treatment was significantly lower than that 6 h after treatment [BNP(478.1 ± 95.3)ng/L vs.(1 025.2 ± 263.3) ng/L,cTnI(0.9 ± 0.1) μ g/L vs.(2.5 ± 0.4) μ g/L,blood lactate(2.4 ± 0.3) mmol/L vs.(5.4 ± 2.1) mmol/L,APACHE Ⅱ score(11.4 ± 1.8) scores vs.(15.6 ± 2.9) scores] (P ＜ 0.05).Conclusion BNP,cTnI,blood lactate and APACHE Ⅱ score may be used to evaluate the severity of sepsis shock patients with myocardium injury and predict outcome of the patients.