Effect of compound Minwei syrup on serum IL-4 and IFN-γ in patients with chronic urticaria / 中国基层医药

ABSTRACT

Objective To study the effect of compound Minwei syrup on serum interleukin-4 (IL-4) and interferon-γ(IFN-γ) in patients with chronic urticaria.Methods 189 patients with chronic urticaria were enrolled as the observation group,60 cases of non-allergic diseases were selected as the control group.The observation group was treated by compound Minwei syrup for average 7 days.Serum levels of IL-4 and IFN-γbefore and after treatment were detected.Results After treatment,in the observation group 123 cases recovered,34 cases had marked effect,effective in 23 cases,9 cases without effect,the total effective rate was 95.2％.Serum IL-4 in the observation group before treament was significantly higher than the control group(t =3.729,P ＜ 0.01),IFN-γwas significantly lower than the control group(t =3.064,P ＜ 0.01).After treatment,serum IL-4 in the observation group was significantly lower than before treatment (t =2.778,P ＜ 0.05),1FN-γwas significantly higher than the control group (t =2.467,P ＜ 0.05).Mild drowsiness and sleepiness appeared in 2 patients in the observation group,symptoms disappeared after drug withdrawal.Conclusion Minwei syrup can significantly improve IL-4 and IFN-γ balance in patients with chronic urticaria.