Clinical significance and changes of serum sex hormone levels in patients with hepatocellular carcinoma / 中国基层医药

ABSTRACT

Objective To explore the changes and clinical significance of sex hormone levels in patients with hepatocellular carcinoma.Methods The serum levels of estrodiol,testosterone,prolactin and E2/T ratio in normal control group(n =28),liver cirrhosis patients (n =28) and hepatocellular carcinoma patients (n =28) were determined by using chemiluminescente microparticle immunoassay method.All the data collected were calculated by the statistic software SPSS13.0 and ANOVA.Results In hepatocellalar carcinoma patients,the serum E2 (221.93 ±11.78) pmol/L,PRL (1.48 ± 0.02) nmol/L and E2/T ratio (3 889.37 ± 14.28) were significantly higher than those of normal controlE2(117.64 ±5.18)pmol/L,PRL (0.78 ±0.17) nmol/L,E2/T (558.23 ±11.19),while serum T level (0.06 ±0.08)nmol/L in hepatocellular carcinoma patients was significantly lower than that of normal control group (0.21 ± 0.07) nmol/L (t =17.52,10.73,1 1.12,14.69,all P ＜ 0.05).The comparison of sex hormone levels and E2/T ratio between metastasis patients and those without metastasis in hepatocellular carcinoma patients had no statistically significant difference (P ＞ 0.05).Conclusion Sex hormones levels were related with the hepatocellular carcinoma development.The higher level of serum E2/T ratio would indicate poor prognosis.