Efficacy and impact on urinary protein of mycophenolate mofetil on primary nephrotic syndrome / 中国基层医药

ABSTRACT

Objective To study the effect of mycophenolate mofetil(MMF) on primary nephrotic syndrome and the impact on urinary protein.Methods According to the digital table,136 cases of nephrotic syndrome were randomly divided into MMF group and control group,68 cases in the control group were dealed with conventional treatment,MMF group was treated with MMF.After 6 months,the treatment effects of both groups were evaluated.Results The overall response rate of MMF group was 82.8％,higher than that of control group 60.6％ with statistically significant difference (x2 =10.86,P ＜ 0.05),;Blood urea nitrogen(BUN),serum creatinine(Scr),24 h urinary protein of two groups had varying degree of reduction,the indexes of MMF group decreased even more significant (t =2.50,4.59,11.12,all P ＜ 0.05).Serum albumin of the two groups had risen,but MMF group increased more significantly (t =3.09,P ＜ 0.05).Conclusion The advantages of MMF are significant effect,reduction in side effects,safe and reliable on nephrotic syndrome and urinary protein,which is worthy of clinical use.