Determination of Residual Organic Solvents in Dimemorfan Phosphate by GC / 中国药师
China Pharmacist
;
(12): 563-565, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-448071
ABSTRACT
Objective:
To determine the content of chloroform, ethyl acetate and DMF in dimemorfan phosphate by gas chromatog-raphy (GC).Methods:
The capillary gas chromatography was used with a PEG-20M column, programmed temperature, water as the solvent and FID as the detector.Results:
The three organic solvents were separated and showed good linear relationship (r>0. 999 0). The detection limit of chloroform, ethyl acetate and DMF was 0. 63,0. 60 and 8. 92μg·ml-1 , respectively. The residues of the organ-ic solvents in three batches of the samples all met with the requirements of ICH.Conclusion:
The method is sensitive, accurate and reliable, and can be used in the quality control of dimemorfan phosphate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
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