Distribution and antimicrobial resistance of Pseudomonas aeruginosa in a county-level hospital / 中国感染控制杂志

ABSTRACT

Objective To analyze the distribution and antimicrobial resistance of Pseudomonasaeruginosa(P. aeruginosa)in a county-level hospital,provide reference for rational antimicrobial use,and promote the control and prevention of healthcare-associated infection (HAI).Methods Data of P.aeruginosaisolated from patients in a hospital between 2010 and 2012 were analyzed statistically.Results A total of 369 P.aeruginosaisolates were iso-lated,strains were mainly from specimens of sputum(n= 234,63.41% ),urine(n= 41,11.11% )and wound(n= 28, 7.59% );most strains were from intensive care unit(n= 146,39.56% ),respiratory diseases department(n= 51, 13.82% )and neurosurgical department(n= 37,10.03% ).P.aeruginosastrains were not resistant to polymyxin B;the resistance rates to imipenem,meropenem,cefoperazone/sulbactam,piperacillin/tazobactam and amikacin were all low(6.81% -22.73% );from 2010 to 2012,resistance rates to antimicrobial agents (except polymyxin B) increased with varying degrees,some antimicrobial agents showed statistical difference(P<0.05).Conclusion P. aeruginosais mainly isolated from respiratory specimens,mainly distributed in departments with serious patients;and resistance to most antimicrobial agents is high,resistance tendency is increasing,surveillance should be intensi-fied.