Human 8-oxoguanine DNA glycosylase and lung cancer / 国际肿瘤学杂志

ABSTRACT

Dysfunction of the human 8-oxoguanine DNA glycosylase (hOGG1) is closely related to development of lung neoplasms and other cancers.Polymorphisms in hOGG1 gene may alter glycosylase activity,thereby affect its repair capacity to the damaged DNA,contributing to carcinogenesis.Joint effects of hOGG1 and other DNA repair gene SNPs have showed complex gene-gene interactions may significantly contribute to people's lung cancer susceptibility.HOGG1 plays an important role in maintaining mitochondrial respiration thus affects tumor cell growth.