Research progress of autophagy and tumor stem cells / 国际肿瘤学杂志

ABSTRACT

Cell autophagy is a lysosome dependent degradation pathway which is characterized by cytoplasm vacuoles.It is important to maintain cell internal environment.The abnormal autophagy is associated with oncogenesis closely.The tumor stem cells which rarely exist in tumor tissues have stem cell properties.They can induce tumor generation and also play an important role in the development,metastasis and recurrence of tumor.The regulation of autophagy in tumor stem cells is the research hotspot,which will provide a new theoretical foundation for the clinical treatment of tumors.