The immune effect of combined immunization for newborns of pregnant women with HBeAg-negative chronic hepatitis B / 中国医师进修杂志

ABSTRACT

Objective To evaluate the immune effect of combined immunization for newborns of pregnant women with HBeAg-negative chronic hepatitis B.Methods Three hundred and seventy-five cases of children given birth by 326 cases of HBeAg-negative HBV-infected pregnant women were enrolled in this study.The usage of hepatitis B immunoglobulin (HBIG) during pregnancy,mode of delivery,the child's immunization measures after the birth and feeding patterns were recorded,and compared the HBV markers.Results All of 375 cases of children were given HBIG after delivery for 12 h,352 (93.9％) cases of children were given the first time of hepatitis B vaccines(HepB) after delivery for 24 h,and 23 (6.1％) cases of children were delayed because of all kinds of neonatal disease,but they were given vaccination after delivery for 7-42 d.Two hundred and thirty-six cases of cord blood were detected for HBV markers,39 (16.5％) cases were HBsAg positive,197 (83.5％) cases were HBsAg negative.The positive rate of anti-HBs and the meta-concentration of anti-HBs in the child with HBsAg positive and HBsAg negative of cord blood had no significant difference (P ＞ 0.05).The positive rate of anti-HBs of children whose mothers used HBIG or not during pregnancy were 63.5％ (47/74),59.8％(180/301).The positive rate of anti-HBs in cesarean section group and the nature delivery group were 65.2％ (103/158),57.1％ (124/217).The positive rate of anti-HBs in breast feeding,mixed feeding and artificial feeding group were 62.0％ (119/192),58.9％ (63/107),59.2％(45/76).There was no significant difference(P ＞ 0.05).Conclusions After normal HBIG combined HepB,different mode of delivery,feeding,third trimester whether given HBIG have no effect on the newborns of pregnant women with HBeAg-negative chronic hepatitis B.