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Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child
Journal of the Korean Pediatric Society ; : 1591-1595, 2002.
Article in Korean | WPRIM | ID: wpr-44854
ABSTRACT
Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyps / Adenoma / Sulindac / Colectomy / Adenomatous Polyposis Coli / Celecoxib Limits: Child / Female / Humans Language: Korean Journal: Journal of the Korean Pediatric Society Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyps / Adenoma / Sulindac / Colectomy / Adenomatous Polyposis Coli / Celecoxib Limits: Child / Female / Humans Language: Korean Journal: Journal of the Korean Pediatric Society Year: 2002 Type: Article