Synthesis and structure-activity relationship of cycloberberine as anti-cancer agent / 药学学报
Acta Pharmaceutica Sinica
; (12): 1800-6, 2013.
Article
in Zh
| WPRIM
| ID: wpr-448790
Responsible library:
WPRO
ABSTRACT
A series of cycloberberine derivatives were designed, synthesized and evaluated for their anti-cancer activities in vitro. Among these analogs, compounds 6c, 6e and 6g showed strong inhibition on human HepG2 cells. They afforded a potent effect against DOX-resistant MCF-7 breast cells as well. The primary mechanism showed that cell cycle was blocked at G2/M phase of HepG2 cells treated with 6g using flow cytometry assay. It significantly inhibited the activity of DNA Top I at the concentration of 0.1 mg mL-1. Our results provided a basis for the development of this kind of compounds as novel anti-cancer agents.
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Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article