Comparison of Ferucarbotran-Enhanced MRI and Triple-Phase MDCT for the Detection of Hepatocellular Carcinoma in Advanced Liver Cirrhosis
Journal of the Korean Radiological Society
;
: 53-63, 2008.
Article
in English
| WPRIM
| ID: wpr-44933
ABSTRACT
PURPOSE:
To compare the diagnostic performance of ferucarbotran-enhanced MRI at 1.5-T with triple-phase multidetector-row helical CT (MDCT) to detect hepatocellular carcinoma in patients with advanced liver cirrhosis. MATERIALS ANDMETHODS:
Twenty patients with advanced liver cirrhosis (Child's class BC = 812) underwent ferucarbotran-enhanced MRI and triple-phase MDCT prior to liver transplantation. The mean time interval between the two imaging techniques was 18 days (range, 1-35 days). Three radiologists independently reviewed both images on a lesion-by-lesion basis and interpreted them for comparison with the pathologic findings of the explanted livers. As well, the sensitivity and an alternative-free response receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance of each technique.RESULTS:
The mean area under the ROC curve (Az) was significantly higher for the triple-phase MDCT (0.766) compared to the ferucarbotran-enhanced MRI (0.675) (p < 0.001). Similarly, the mean sensitivity of the triple-phase MDCT (60.3%) exceeded the ferucarbotran-enhanced MRI (43.1%). The results indicate that the triple-phase MDCT provides significantly greater mean sensitivity than the ferucarbotran-enhanced MRI (p < 0.001).CONCLUSION:
The triple-phase MDCT provided a better diagnostic performance and higher sensitivity than the ferucarbotran-enhanced MRI for the detection of hepatocellular carcinomas in patients with advanced liver cirrhosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
ROC Curve
/
Dextrans
/
Liver Transplantation
/
Carcinoma, Hepatocellular
/
Tomography, Spiral Computed
/
Magnetite Nanoparticles
/
Liver
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Radiological Society
Year:
2008
Type:
Article
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