Changes of gene expression profile of multiple myeloma cell line RPMI 8226 treated by arsenic trioxide / 中西医结合学报
Journal of Integrative Medicine
;
(12): 160-5, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-449617
ABSTRACT
OBJECTIVE:
To compare the changes of gene expression profiles of multiple myeloma cell line RPMI 8226 before and after 24-hour intervention of arsenic trioxide.METHODS:
The responses of the RPMI 8226 cells to arsenic trioxide were determined with cDNA microarray which included 4,096 different human genes.RESULTS:
Of these 4,096 genes, the expressions of 273 genes were altered significantly at mRNA level. The expressions of 121 genes were up-regulated while the expressions of 152 genes were down-regulated.CONCLUSION:
The effect of arsenic trioxide on RPMI 8226 cells is related to changing the expression levels of a number of genes. ZFYVE16, ALK1 and TXNIP genes may play important roles in apoptosis and differentiation of RPMI 8226 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Integrative Medicine
Year:
2006
Type:
Article
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