Effect of Zhenju Jiangya Tablet on the endothelial function of hyperlipidemic rabbits / 中西医结合学报
Journal of Integrative Medicine
;
(12): 111-4, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-449889
ABSTRACT
OBJECTIVE:
To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits.METHODS:
Male New Zealand rabbits were randomized into four groups control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated.RESULTS:
ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14+/-0.26), (1.74+/-0.59), (1.22+/-0.37) and (1.17+/-0.41) respectively. The eNOS of each group was (4.21+/-0.37), (1.43+/-0.88), (3.95+/-0.67) and (4.08+/-0.46) nmol x min(-1) x g(-1) respectively.CONCLUSION:
ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Journal of Integrative Medicine
Year:
2004
Type:
Article
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