Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats / 中西医结合学报
Journal of Integrative Medicine
;
(12): 39-41, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-449916
ABSTRACT
OBJECTIVE:
To investigate the therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy.METHODS:
Diabetic rats were induced by streptozotocin. They were divided into 5 groups normal control group (group C), untreated diabetic group (group DM), tetromethylpyrazine treated group (group TMP), aminoguanidine treated group (group AG) and tetromethylpyrazine and aminoguanidine treated group (group TMP+AG). The expression of vascular endothelial growth factor (VEGF) in renal cortex of the rats in each group was observed by immunohistochemical staining after 12 weeks.RESULTS:
The expression of VEGF in renal cortex of the rats in group TMP+AG and group C was alike. The expression of VEGF in renal cortex of group TMP and group AG decreased significantly as compared with that of group C, but was still above normal level.CONCLUSION:
The therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy may be inhibiting the over-expression of VEGF in kidney of diabetic rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Integrative Medicine
Year:
2004
Type:
Article
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