Gap junctions and epilepsy / 国际儿科学杂志

ABSTRACT

Gap junction,a special structure in cell membrane,constitutes the only direct communication channel of energy,material and information exchange between adjacent cells.Gap junction plays an important role in the maintenance of electrical activity of neurons,the rapid synchronization of neurons and neuronal development.Epilepsy,caused by a variety of causes,is a complex clinical syndrome.The pathogenesis of epilepsy is complex.And it's still not fully understood.Studies in recent years have found that gap junction plays a very important role in the pathogenesis and development of epilepsy.The structure,distribution and functions of gap junction and the relationship between gap junction and epilepsy are reviewed in the paper.