High Sensitivity CRP, Fibrinogen and Homocysteine in Relation to Carotid Intima-media Thickness in Acute Ischemic Stroke / 고신대학교의과대학학술지
Kosin Medical Journal
;
: 149-154, 2011.
Article
in Korean
| WPRIM
| ID: wpr-45055
ABSTRACT
OBJECTIVE:
To evaluate the relationship of high sensitivity C-reactive protein (hs-CRP), fibrinogen and homocysteine to carotid intima-media thickness (IMT) in acute ischemic stroke.METHODS:
Subjects were 347 patients with acute cerebral infarction. The carotid arterial wall thickness was measured using high resolution B-mode ultrasound. The serum levels of hs-CRP, fibrinogen and homocysteine were measured by latex-enhanced turbidimetric immunoassay, clot scattering method, and chemiluminescence immunoassay respectively. Univariate regression analysis was performed to evaluate the relationship between these levels and carotid IMT.RESULTS:
In patients with acute ischemic stroke, carotid IMT was significantly correlated with increased serum levels of hs-CRP and fibrinogen (P < 0.05, P < 0.01, respectively). However association between serum homocysteine and carotid IMT was not statistically significant.CONCLUSIONS:
Increased serum levels of hs-CRP and fibrinogen may be correlated with carotid IMT. Measurement of serum hs-CRP and fibrinogen may be helpful for predicting degrees of atherosclerosis in acute ischemic stroke.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
C-Reactive Protein
/
Fibrinogen
/
Immunoassay
/
Cerebral Infarction
/
Stroke
/
Luminescence
/
Atherosclerosis
/
Carotid Intima-Media Thickness
/
Homocysteine
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Kosin Medical Journal
Year:
2011
Type:
Article
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