Effect of milrinone on refractory heart failure / 中国基层医药

ABSTRACT

Objective To investigate the effects of the milrinone in adjuvant treatment of intractable heart failure.Methods 60 cases of patients with intractable heart failure were randomly divided into observation group and control group according to hospitalization sequence,30 cases each group.The control group was given conventional therapy for heart failure,the observation group based on the use of milrinone.Changes of cardiac function index,NT-proBNP were compared between two groups before and after medication,and recorded the adverse reactions and the efficacy evaluation.Results After taking drugs,HR,LVEDD of the two groups were significantly decreased(t =5.31,5.92,4.61,4.22,all P ＜ 0.05),SV,LVEF and 6 minutes walking distance increased significantly(t =7.22,4.78,8.78,4.56,4.11,4.05,all P ＜ 0.05) ; group HR,LVEDD were significantly lower than those in the control group(t =4.31,4.92,all P ＜0.05).SV,LVEF and 6-minute walking distance was significantly higher than that in the control group(t =4.31,4.92,4.11,all P ＜ 0.05).After taking drugs,the observation group NT-proBNP levels decreased significantly than before treatment (t =14.55,P ＜ 0.05),and significantly lower than that in the control group (t =7.12,P ＜ 0.05).No significant change in NT-proBNP levels before and after treatment in control group was found (t =1.03,P ＞ 0.05).The observation group in the total effective rate was 93.33 ％ (28/30),the control group was 63.33％ (19/30),the difference was statistically significant(x2 =5.26,P ＜ 0.05).5 cases of adverse reactions to the observation group,4 patients in the control group,no significant difference in the adverse reactions was found between the two groups (x2 =0.67,P ＞ 0.05).Conclusion Low dose,short-term use of milrinone can make the heart function of patients with refractory heart failure was obviously improved,significantly improve the efficacy with higher safety.