Analysis of infected characters and its related factors of nosocomial infection in children leukemia / 中国综合临床

ABSTRACT

Objective To explore the related factors of nosocomial infection in children with leukemia and its character.Methods Retrospective analyzed 96 leukemia children with nosocomial infection who were come from 220 patients with acute leukemia.The information of the infection rate at different chemotherapy stages,different hospitalization time,site of infection and strain condition were recorded.Results (1) The infection rate of leukemia children at induction and consohdation stage were 85.7％ (24/28) and 76.7％ (23/30) respectively.(2) The infection rate increased with the duration of hospitalization periods.The infection rate was 8.6％ (3/35) at 0-7 d hospitalization periods and 62.7％ (42/67) at 15-30 d hospitalization periods.(3) The infection was prone to occurring at respiratory tract (58.3％,56/96),followed by gastrointestinal tract (17.7％ (17/96)),blood (13.5％ (13/96)),skin (8.3％ (8/96)) and other parts (2.1％ (2/96)).(4) The most frequency stain listed as Escherichia coli(21.8％ (26/96)),and Citrobacter (16.8％ (20/96)).The lower detection rates of the bacteria listed as Candida albicans (2.5％ (3/96)),Aspergillus(1.7％ (2/96)) and yeast (0.8％ (1/96)).Condusion Even though the survival rates of leukemia children is increasing due to technology development,nosocomial infection frequently occur.The high infection rates occur at chemotherapy induction and consolidation phase.Therefore intervention should be taken based on nosocomial infection in children leukemia such improving the environment of ward,enhancing the immune ability of children in order to decrease the incidence of hospital infection.