Relation between serum human cartilage glycoprotein and vascular endothelium of old hypertensive patients with metabolic syndrome / 中国综合临床

ABSTRACT

Objective To explore the concentration changing of human cartilage glycoprotein in elder hypertension patients with metabolic syndrome.Methods Thirty healthy people were served as control group.While 68 elder hypertension patients with metabolic syndrome were served hypertension group and they were divided into MS group and Non-MS group based on data of metabolic syndrome(MS) indicators.The serum YKL-40 concentration was measured by ELISA method,and the levels of hepatocyte growth factor(HGF),nitric oxide(NO),endothelin(ET) were also measured.Brachial artery flow mediated vasodilation(FMD) was used to assess endothelial function.Compared the difference of serum YKL-40 concentration of two groups and the relationship between YKL-40 and index of endothelial function.Results The concentration of serum YKL-40 in hypertension group was 51.8 (35.4,345.0) μg/L,higher than that of control group (33.4 (23.6,168.6)μg/L,Z =-3.156,P ＜ 0.01).The YKL-40 levels in control group,hypertemion group,Non-hypertension MS group,and hypertension MS group were 33.4 (23.6,168.6),51.8(35.4,345.0) μg/L,94.0(46.0,268.4),and 151.6(63.2,401.4) μg/L respectively,and the difference was significant.Serum YKL-40 concentration in hypertension group was higher than that of control group (Z =-3.156,P ＜ 0.01),while in hypertension MS group was higher than that of non-MS hypertension group(P =0.003).Of all study subjects,YKL-40 level was positively related to systolic blood pressure,diastolic blood pressure,body mass index,triglyceride (r =0.362,0.302,0.280,0.217,P ＜ 0.05) and was not corelate with FMD,ET,NO,HGF (P ＞ 0.05).Conclusion Serum YKL-40 concentration in patients with hypertension is related to blood pressure and not related to functional factors of vascular endothelium.