Predictors of Steroid Treatment Failure and Validation of Previous Models for Severe Attacks of Ulcerative Colitis
Intestinal Research
;
: 251-264, 2012.
Article
in Korean
| WPRIM
| ID: wpr-45086
ABSTRACT
BACKGROUND/AIMS:
Some clinical and laboratory parameter are predictors to determine steroid treatment failure in patients acute severe ulcerative colitis. We aimed to validate previous models in the Korean patients.METHODS:
This study was conducted retrospectively with 70 patients who were diagnosed with severe ulcerative colitis (UC) between January 2001 and June 2011. The rate of treatment failure was investigated using predictors or numerical scoring systems from prior studies.RESULTS:
Twelve (17.2%) patients failed to respond to steroid therapy. The logistic regression analysis revealed that stool frequency on the fifth day and colonic dilatation were the only independent predictive factors related to treatment failure. Formulated numerical risk scores based on mean stool frequency, colonic dilatation, and hypoalbuminemia were significantly higher in the non-responding group than those in the responding group (P8 than in the group with a score 8 plus CRP >4.5 mg/dL or bloody stool plus CRP >4.3 mg/dL) than those of the other group at the third day (40% vs. 7.3%, P=0.004; 33.3% vs. 5.2%, P=0.014, respectively).CONCLUSIONS:
Stool frequency and CRP level were the meaningful parameters among the predictors for steroid treatment response. Furthermore, several predictive models for steroid treatment failure in western countries seem to be of value for use in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ulcer
/
Colitis, Ulcerative
/
Logistic Models
/
Retrospective Studies
/
Treatment Failure
/
Adrenal Cortex Hormones
/
Colon
/
Hypoalbuminemia
/
Dilatation
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Intestinal Research
Year:
2012
Type:
Article
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