Effect of hyperbaric oxygen on patients with severe traumatic brain injury and on intracranial hemodynamics / 军事医学

ABSTRACT

Objective To investigate the effect of hyperbaric oxygen on cerebral hemodynamics and intracranial pressure(ICP)in patients with severe traumatic brain injury (SBI).Methods A retrospective analysis was conduccted .82 cases of SBI patients treated in our hospital from January 2013 to January 2014 were randomly and evenly divided into two groups.Control group received conventional treatment while observation group was treated with continuous hyperbaric oxygen therapy.Intracranial hemodynamic parameters before and after treatment were determined and compared between the two groups.Results Peak systolic velocity ( Vs) and mean flow velocity ( Vm) of the middle cerebral artery ( MCA) were faster in hyperbaric oxygen group than in control group (P<0.05); the pulsatility index was lower than in control group (P<0.05);intracranial pressure (ICP) values (11.20 ±3.39)mmHg were significantly lower in observation group after hyperbaric oxygen therapy than in control group (15.24 ±3.13)mmHg.The difference was statistically significant (P<0.05), and the total effective rate was 85.37% vs 68.29% in control group(P<0.05).Conclusion Early hyperbaric oxygen therapy can significantly enhance SBI patients immune function and the ability to fight against infections in critically ill patients, therefore improving patients outcomes and overall quality of life .