The analysis of clinic and pathology in children with primary nephrotic syndrome / 中国医师杂志

ABSTRACT

Objective To investigate the relationship of clinic and pathology in children with pri-mary nephrotic syndrome to predict the pathological classification .Methods Retrospective analysis of the relationship of clinical manifestations and therapy in 46 hospitalized children with primary nephrotic syn-drome.Results The main clinical manifestations in 46 patients were proteinuria, hematuria, hyperten-sion, renal insufficiency, the renal pathological type were 18 (39.1%) mesangial proliferative glomerulone-phritis, 14 (30.4 %) minimal change nephropathy , 11 (23.9%) focal segmental glomerulosclerosis , 2 (4.3%) membrane proliferative glomerulonephritis , and 1 (2.3%) membranous nephropathy , respective-ly.Mesangial proliferative glomerulonephritis and minimal change nephropathy patients responded well to treatment, but focal segmental glomerulosclerosis , membranoproliferative glomerulonephritis and membra-nous nephropathy responded poorly to treatment .Conclusion Children with primary nephrotic syndrome mainly showing mesangial proliferative glomerulonephritis and minimal change nephropathy have good re -sponse to treatment.However, primary nephrotic syndrome children with clinical manifestations of hematuri-a, hypertension, renal insufficiency or poor response to treatment should perform renal biopsy .