The protective effects of resveratral on acute radiation injury in mice / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
;
(12): 512-515, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-451772
ABSTRACT
Objective To study the protective function of resveratrol on radiation-induced small intestine injury and lethal effect in mice.Methods Mice were randomly divided into three groupsirradiation (IR) control,IR only,and IR + resveratrol.15 mice each group were irradiated on abdomen with 7.2 Gy γ-rays for cell lethal assay and 8 mice each group were irradiated with 6.5 Gy for small intestine injury assay.For the IR + resveratrol group,the mouse was given resveratrol by intragastric administration 24 h before irradiation and then was fed with resveratrol daily for 5 days.The control and IR alone groups were fed with placebo.After 30 days of IR,mouse survival rate was detected.For small intestine injury experiments,24 h after IR,the mice were terminated and the small intestines were treated with HE and immunohistochemical staining.Results Compared with the irradiation group,resveratrol increased mouse survival by 33.3%,decreased apoptosis in intestinal crypt cells (t =17.35,P < 0.05),and increased Ki67 expression (t =13.62,P < 0.05).Conclusion Resveratrol could protect small intestine injury from ionizing irradiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Radiological Medicine and Protection
Year:
2014
Type:
Article
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