Research progress on drugs targeting p53 / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 912-916, 2014.
Article
in Zh
| WPRIM
| ID: wpr-451915
Responsible library:
WPRO
ABSTRACT
With the understanding of the development and pro-gress of the cancer,the research of targeted cancer drug devel-opment reaches into a new era.p53 is an important tumor sup-pressor gene,the protein coded by p53 plays a critical role in tumor suppression mainly by inducing cell cycle regulation, DNA repair and apoptosis.Nowadays,p53 becomes a relatively attractive target for anti-cancer drug development and there are some drugs targeting p53,moreover,APR-246 which targets mutant p53 is in Phase II clinical trial.In addition,it facilitates drugs discovery programmes in the challenging area of protein-protein interactions and mutant protein conformational change. The review discusses the research progress of drugs which target p53 and elucidates the characteristics and mechanisms of these compounds.
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WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2014
Type:
Article