Your browser doesn't support javascript.
loading
Research progress on drugs targeting p53 / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 912-916, 2014.
Article in Zh | WPRIM | ID: wpr-451915
Responsible library: WPRO
ABSTRACT
With the understanding of the development and pro-gress of the cancer,the research of targeted cancer drug devel-opment reaches into a new era.p53 is an important tumor sup-pressor gene,the protein coded by p53 plays a critical role in tumor suppression mainly by inducing cell cycle regulation, DNA repair and apoptosis.Nowadays,p53 becomes a relatively attractive target for anti-cancer drug development and there are some drugs targeting p53,moreover,APR-246 which targets mutant p53 is in Phase II clinical trial.In addition,it facilitates drugs discovery programmes in the challenging area of protein-protein interactions and mutant protein conformational change. The review discusses the research progress of drugs which target p53 and elucidates the characteristics and mechanisms of these compounds.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2014 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2014 Type: Article