Distribution and drug resistance of fungi isolated from urinary tract infection / 国际检验医学杂志

ABSTRACT

Objective To understand the distribution and drug resistance of fungus isolated from urinary tract infection for guid-ing clinical rational drug use.Methods The clinically submitted urinary system samples from January 2012 to June 2013 were per-formed the fungal identification and the drug susceptibility test to 5 kinds of anti-fungal drugs.The detection results were analyzed by the WHONET software.Results (1)239 strains of fungi were isolated,in which Candida albicans occupied the top place,fol-lowed by Candida glabrata and Candida tropicalis;(2)the sensitivity rates of 239 fungal strains to fluconazole(FCA),itraconazole (ITR),voriconazole(VRC),5-fluorocytosine(5-FC)and amphotericin B(AMB)were 63.2%,61.9%,92.5%,93.7% and 93.7%respectively;(3)Candida albicans had the high sensitivity to 5 kinds of anti-fungal drugs,which reached more than 95%;(4)Candida gla-brata had the lowest sensitivity to FCA and ITR,only 9.7%.Conclusion The fungal infection in the urinary system is dominated by Candi-da albicans,due to the different sensitivity to 5 kinds of anti-fungal drugs in different fungi,therefore strengthening the fungal identification of the urinary system and the drug sensitivity test can provide the important reference basis for clinical rational use of anti-fungal drugs.