Therapeutic effect of different dosages of metoprolol combined amiodarone on tachyarrhythmia / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine
;
(6): 297-300, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-451990
ABSTRACT
Objective:
To compare clinical therapeutic effects of different dosages of metoprolol combined amioda-rone on patients with tachyarrhythmia.Methods:
A total of 120 patients with tachyarrhythmia were randomly divid-ed into small-dose group (n=40,received 5mg/d metoprolol),medium-dose group (n=40,received 10mg/d meto-prolol)and large-dose group (n=40,received 15mg/d metoprolol)according to number table method.Each group received combined amiodarone therapy.Clinical indexes such as acting time,sinus rhythm conversion rate and left ventricular ejection fraction (LVEF)were compared among three groups.After three-month follow up,recurrence rate of tachyarrhythmia was compared among three groups.Results:
Compared with small-dose group,there was significant reduction in acting time [(7.2±1.1)h vs.(3.4±1.0)h,(2.9±0.8)h],and significant rise in sinus rhythm conversion rate (57.5% vs.85.0%,90.0%)and effective rate (62.5% vs.90.0%,95.0%)in medium-dose group and large-dose group,P0.05 all).There were no significant differences in mean blood pressure and heart rate,LVEF and incidence rates of all kinds of adverse reactions among three groups (P>0.05).After three-month follow-up,recurrence rate of medium-dose group (2.5%)was significantly lower than those of large-dose group (10.0%)and small-dose group (20.0%),P<0.05.Conclusion:
Medium dosage of metoprolol combined with amio-darone possesses more clinical therapeutic effect than small-dose and large-dose in patients with tachyarrhythmia;it is worth extending in clinic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of cardiovascular Rehabilitation Medicine
Year:
2014
Type:
Article
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