Therapeutic effect of atorvastatin combined trimetazidine on treating unstable angina pectoris / 心血管康复医学杂志

ABSTRACT

Objective:To study the therapeutic effect of atorvastatin (ATO)combined trimetazidine (TRZ)on un-stable angina pectoris (UPA).Methods:A total of 100 UAP patients in our hospital from Mar 2011 to Mar 2013 were enrolled.According to number table method,they were randomly divided into ATO group (received ATO ad-ditionally based on routine medication,n=50)and ATO+TRZ group (received TRZ additionally based on ATO group treatment,n=50).Levels of blood lipids and therapeutic effects were compared between two groups before and after treatment.Results:Total effective rate was 96.00% (48/50)in ATO+TRZ group,which was signifi-cantly higher than that of ATO group (76.00%),P<0.05.Compared with ATO group,there were significant re-ductions in levels of total cholesterol [TC,(4.78±0.65)mmol/L vs.(4.12±0.60)mmol/L],triglyceride [TG, (1.54±0.51)mmol/L vs.(1.02±0.53)mmol/L]and low density lipoprotein cholesterol [LDL-C,(3.02±0.46) mmol/L vs.(2.32±0.45)mmol/L],and significant rise in level of high density lipoprotein cholesterol [HDL-C, (1.57±0.58)mmol/L vs.(2.12±0.55)mmol/L]in ATO+TRZ group,P<0.05 all.Conclusion:Atrovastatin combined trimetazidine can more significantly improve therapeutic effect in patients with unstable angina pectoris, which should be recommended in clinic.