Preparation of Nifedipine Sustained-Release Pellet Tablets and Study of Its Release Behavior in vitro / 医药导报
Herald of Medicine
;
(12): 790-793, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-452077
ABSTRACT
Objective To prepare nifedipine( NF)sustained-release pellet tablets,and study of its release behavior in vitro. Methods Soluplus was selected as a carrier to prepare solid dispersion of NF by hot melt extrusion technique( HME), and the ratio of the drug to carrier was 11. The samples were validated as the solid dispersion by differential scanning calorimetry(DSC). Extrusion-spheronization technique was introduced to prepare NF pellets and EudragitRS 30D was used as the coating material. The NF sustained-release tablets were prepared by direct compression of the coated pellets and suitable excipients. Results The release data in vitro proved that the drug release from the tablets was steady and complete over 24 hours. Conclusion The release of NF from sustained-release tablets is slow and steady. The method is easy to operate. The in vitro drug release pattern follows first-order kinetics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Herald of Medicine
Year:
2014
Type:
Article
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