Cellular plasticity and tumor therapy resistance:research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 268-274, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-452223
ABSTRACT
Drug resistance,tumor relapse and metastasis remain the main obstacles to the success of cancer treatments. Chemotherapies,targeted therapies and immunotherapies can successfully achieve remissions in cancer patients,but durable responses are rare. Although the mechanisms of diverse therapies vary,plasticity alteration of tumor and immune cells in response to therapy-induced tumor tissue injury and inflammation contributes to the development of drug resistance. This review summarizes research progress in the adaptive phenotypic plasticity of tumor cells and immune cells during tumor progression as well as the successful combination of targeted therapy and immunotherapy in cancer treatment to tackle resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS