Recent advances in cancer-associated circulating cell-free nucleic acids / 中国癌症杂志
China Oncology
; (12): 469-475, 2014.
Article
in Zh
| WPRIM
| ID: wpr-452232
Responsible library:
WPRO
ABSTRACT
Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly higher than in healthy people. Further studies showed that the genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression, including mutation, hypermethylation, loss of heterozygosity, change of integrity, and abnormal expression of microRNAs. Detection of circulating cell-free nucleic acids shows promising potential in cancer screening, diagnosis, personalized treatment, and prognosis.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
China Oncology
Year:
2014
Type:
Article