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Determination of Bisphenolic and Halogenated Bisphenolic Compounds in Human Urine by High Performance Liquid Chromatography-Tandem Mass Spectrometry / 分析化学
Chinese Journal of Analytical Chemistry ; (12): 1053-1056, 2014.
Article in Chinese | WPRIM | ID: wpr-452352
ABSTRACT
A method was developed for the determination of four kinds of bisphenolic and halogenated bisphenolic compounds including bisphenol F, bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A in human urine using high performance liquid chromatography-tandem mass spectrometry. The analytes was extracted by solid phase extraction. The separation of the analytes was achieved on an Atlantis T3 column (3. 0×150 mm, 3 μm) gradient eluted with the mobile phase of acetonitrile and water at the rate of 250 μL/min, and detected by an electrospray ionization tandem mass spectrometry in the multiple-reaction-monitoring negative mode. The quantification was carried out by matrix-matched calibration curve. The average recoveries at 3 spiked levels were 86%-118%, with intra-day precision of 2 . 6%-17 . 0% and inter-day precision of 3. 2%-18. 0%. The limits of detection of four analytes (S/N=3) were 0. 01-0. 25 μg/L. The method was applied to the analysis of 200 human urines samples and the results showed that the method was simple, sensitive and reliable.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Analytical Chemistry Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Analytical Chemistry Year: 2014 Type: Article