Association of IL-10 Gene Polymorphism with Development of Atopy / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 381-388, 2005.
Article
in Korean
| WPRIM
| ID: wpr-45244
ABSTRACT
PURPOSE:
There has been accumulating evidence that interleukin-10 (IL-10) influences on the production of proinflammatory cytokines, regulating the development of atopic diseases. In this study, we tested the genetic association between IL-10 haplotype polymorphism and the development of atopy.METHODS:
The frequency of three single nucleotide polymorphisms (SNPs) at positions- 1082 (A/G), -819 (C/T), -592 (A/C) and corresponding haplotypes in the promotor region of the IL-10 gene were analysed in 174 atopic and 130 non-atopic children using Taqman method. The data were assessed for correlations with the eosinophil count and total serum IgE concentration.RESULTS:
Three haplotypes (ATA, ACC, GCC) were identified without any ambiguous phasing due to linkage disequilibrium among SNPs. The frequency of IL-10 haplotype ACC was higher in non-atopic children compared to atopic children. (P=0.04) The frequency of IL-10 haplotype ATA was higher in atopic children compared to non-atopic children, but a statistical significance was not found. (P=0.099) ATA/ATA and ATA/ACC accounted for 80 percent of six different genotypes. Although the frequency of ATA/ATA genotype was higher in atopic children, there was no statistical significance. Although medians of serum IgE level and total eosinophil count were higher among atopic children with ATA/ATA genotype than in atopic children with ATA/ACC, no statistical significance was found.CONCLUSION:
These results suggest that IL-10 promotor polymorphism may be associated with a genetic risk factor for the development of atopy in Korean children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Immunoglobulin E
/
Linkage Disequilibrium
/
Risk Factors
/
Cytokines
/
Promoter Regions, Genetic
/
Interleukin-10
/
Polymorphism, Single Nucleotide
/
Eosinophils
/
Genotype
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
Korean
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2005
Type:
Article
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