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Expression of eosinophil chemotactic factors in stomach cancer
Yonsei Medical Journal ; : 131-136, 1999.
Article in English | WPRIM | ID: wpr-45262
ABSTRACT
We have occasionally experienced eosinophilic abscess of the liver in patients with gastric carcinoma, suggesting that some eosinophil mobilizing (chemotactic and proliferative) factors might be produced by carcinoma cells. The aim of this study was to determine whether or not gastric carcinoma expresses the well-known eosinophil chemotactic factors (ECFs) and whether or not the expression is related to the histologic subtypes. Seventeen consecutive surgically removed tumor-bearing stomachs were collected 7 signet ring cell type, 7 poorly differentiated tubular adenocarcinoma, and 3 moderately differentiated tubular adenocarcinoma. Hematoxylin-eosin stained sections were re-evaluated for eosinophil and mast cell infiltration. The expression of IL-2, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF) were examined by immunocytochemical stain. There was no available frozen tissue for IL-2 and IL-5 in one case. Gastric carcinoma expressed IL-2 in all 16 cases, IL-5 in 12 of 16 cases and GM-CSF in 10 of 17 cases. Of particular interest, 7 of 10 GM-CSF-expressing carcinomas were signet ring cell type. Even in the remaining 3 cases, most GM-CSF-positive cells were signet ring cells scattered within tubular adenocarcinoma. No correlation of ECF expression between either eosinophil/mast cell infiltration or peripheral blood eosinophilia was identified. In conclusion, most gastric carcinomas express the well-known ECFs and the expression of GM-CSF is specific for signet ring carcinoma cells.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Immunohistochemistry / Cell Movement / Chemotactic Factors, Eosinophil / Eosinophils / Mast Cells Type of study: Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Immunohistochemistry / Cell Movement / Chemotactic Factors, Eosinophil / Eosinophils / Mast Cells Type of study: Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 1999 Type: Article