Experimental study on inhibition of autophagy enhancing TRAIL-induced apoptosis in prostate cancer cells / 重庆医学

ABSTRACT

Objective To study whether the TRAIL treating prostate cancer cells can induce autophagy and the role of autoph-agy in it.Methods The expression of autophagy-related protein was detected by Western blot;the toxicity of TRAIL on prostate cancer cells was observed by suppressing autophagy.Results TRAIL could enhance the expression of autophagy-related protein,in-hibiting autophagy could enhance the cytotoxic effect of TRAIL on prostate cancer cells.Conclusion TRAIL can induce the autoph-agy occurrence in prostate cancer and autophagy play a protective role on prostate cancer cells.