The loss of expression of transforming growth factor-beta receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients
Yonsei Medical Journal
;
: 118-123, 1999.
Article
in English
| WPRIM
| ID: wpr-45264
ABSTRACT
Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-beta through a loss of expression of TGF-beta receptors T beta R-I and T beta R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-beta receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T beta R-I and T beta R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-beta receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T beta R-I and T beta R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-beta receptors. However, among grade II TCC samples, T beta R-I and T beta R-II were detected in 78% and 89%, respectively among grade III TCC samples, T beta R-I and T beta R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-beta may play a role in the progression of TCC from low to high grade disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Urinary Bladder Neoplasms
/
Carcinoma, Transitional Cell
/
Receptors, Transforming Growth Factor beta
/
Middle Aged
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS