Effects of dexmedetomidine on anesthesia and postoperative analgesia in children undergoing adenoidectomy and tonsillectomy / 重庆医学

ABSTRACT

Objective To investigate the effects of dexmedetomidine on anesthesia and postoperative analgesia in children under-going adenoidectomy and tonsillectomy.Methods 58 children aged 2-12 years old,ASA rated as Ⅰ or Ⅱ level,scheduled to re-ceive selective adenotonsillectomy were divided into three groups at random,group C(n=22),group D1 (n=18)and group D2 (n=18).The anesthesia induction and the anesthesia maintaining scheme were same in 3 groups.Dexmedetomidine 0.75μg/kg was intr-aoperatively given in the group D1 and D2 ,while the same volume of normal saline was given in the group C as control at the same time.After operation,postoperative analgesia recipe in the group C and D1 was sulfentanyl 2μg/kg,tramadol 5 mg/kg dexametha-sone 0.5 mg and ondansetron 2 mg,which in the group D2 was same except reducing sulfentanyl to 1μg/kg.All were diluted to 100mL by normal saline and given by the same type of disposable infusion pump at a rate of 2 mL/h.The blood pressure and heart rate were observed and recorded before anesthesia induction(T0 ),instantly after endotrachel intubation(T1 ),at 5,10,15,20 min af-ter endotrachel intubation(T2-T5 )and the operation end(T6 );the autonomous respiration recovery time,extubation time,remo-ving monitoring time after operation and drug withdrawal were recorded;the heart rate,respiration rate,SpO2 ,and sedation and an-algesia scores were observed and recorded per 1 h within postoperative 6 h.Results The intraoperative hemodynamics was stable. The postoperative autonomous respiration recovery time,extubation time and removing monitoring time had no statistical differ-ences among 3 groups(P>0.05);during the postoperative observation period,the heart rate,respiration rate,sedation and analgesia scores had no statistical difference among 3 groups(P>0.05).Conclusion Intraoperative dexmedetomidine has no adverse influ-ence on the hemodynamics without affecting the recovery quality after anesthesia and possesses the postoperative analgesic effect.