Incidence and possible reasons for discordant results between positive FDP and negative D-dimer latex assays in clinical specimens
Yonsei Medical Journal
;
: 107-111, 1999.
Article
in English
| WPRIM
| ID: wpr-45266
ABSTRACT
In general, FDP and D-dimer values have a correlation in clinical conditions associated with disseminated intravascular coagulation(DIC) or coagulation activation. However, there are some patients with discordant results who demonstrate elevated FDP and negative D-dimer results by latex agglutination assays. The incidence and possible reasons for the discordance between FDP and D-dimer results were investigated through simultaneous measurements (n = 763) from clinical patients with suspected DIC or coagulation activation. 24.8% (189/763) of samples with elevated FDP were negative for D-dimer assays by the latex agglutination method. Further detailed analysis on randomly-selected discordant samples (n = 41) revealed that the most common reason for the discordance was the lower sensitivity of the semiquantitative latex agglutination method for D-dimer, compared with quantitative enzyme or other latex immunoassay. The other contributing factors to the discordance were accelerated fibrinogenolysis without secondary fibrinolysis, elevated soluble fibrin monomer and rheumatoid factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Coagulation Disorders
/
Fibrin Fibrinogen Degradation Products
/
Latex Fixation Tests
/
Disseminated Intravascular Coagulation
Type of study:
Incidence study
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
1999
Type:
Article
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