Curative Effect Observation of Gynecological Postoperative Patient-Controlled Intravenous Analgesia (PCIA) of Parry Celebrex Sodium Combined with Sulfentanyl / 中国药师

ABSTRACT

Objective: To discuss the curative effect of gynecological postoperative patient-controlled intravenous analgesia ( PCIA) of parry celebrex sodium combined with sulfentanyl. Methods: Totally 66 cases with gynecological operation were randomly divided into the observation group and the control group. The patients in the two groups were both given PCIA of sulfentanyl after the tube withdrawal, and the patients in the observation group were given 40mg parry celebrex sodium respectively before skinning suture and 12 hours after the operation by intravenous injection, while the patients in the control group were given 5ml sodium chloride injec-tion (0. 9%) at the same time. The VAS and Ramsay scores of the patients at the stages of 1h (T1), 2h (T2), 6h (T3), 12h (T4) and 24h (T5) after the operation were observed. The press times of PCIA, effective press times, amount of sulfentanyl, VAS satisfac-tion rates and adverse drug reactions ( ADR) in 24 hours after the operation were recorded. Results:The VAS and Ramsay scores of the patients in the observation group at the different stages were much higher than those in the control group (P<0. 05). The total press times of PCIA, effective press times, amount of sulfentanyl of the patients in the observation group in 24 hours after the operation were much lower than those in the control group (P<0. 05). The VAS satisfaction rate in the observation group was much higher than that in the control group (P<0. 05), and the ADR occurrence rate in the observation group was much lower than that in the control group (P<0. 05). Conclusion:The application of parry celebrex sodium combined with sulfentanyl on PCIA after the operation can reduce the amount of sulfentanyl and enhance the VAS and Ramsay effect with fewer adverse drug reactions, which is a safe and effec-tive VAS method after the operation.