Content Determination of Valacyclovir Hydrochloride Capsules by HPLC / 中国药师
China Pharmacist
;
(12): 238-240, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-452780
ABSTRACT
Objective:
To develop an HPLC method for the determination of valacyclovir hydrochloride capsules.Methods:
An Inertsil ODS (250 mm × 4. 6 mm,5μm) column was employed with methanol-0. 02 mol·L-1 potassium dihydrogen phosphate solution (20∶80) as the mobile phase, the flow rate was 1. 0 ml·min-1, the detection wavelength was at 251 nm, the column temperature was 30℃,and the sample size was 20μl.Results:
The linear range of valacyclovir hydrochloride was 2-40μg·ml-1 , the correlation coeffi-cient was 0. 999 9 and the average recovery was 99. 8%(RSD=0. 16%,n=9).Conclusion:
The analytical method is simple, accu-rate and special, which can be used in the content determination and quality control of valacyclovir hydrochloride capsules.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
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